Ciyarwa tana daidaita matakin insulin da IGF-1. Wadannan hormones suna taka muhimmiyar rawa wajen kiyaye matakin sukari na jini. Wannan binciken yana ba da shawarar cewa waɗannan hormones kuma suna aiki azaman sigina na farko na ciyar da lokaci zuwa agogon jiki. Suna sake saita agogon circadian ta hanyar shigar da sunadaran lokaci. Duk wani siginar insulin da ba na ka'ida ba saboda rashin cin abinci mara kan lokaci yana rushe ilimin halittar jiki da hali da bayyanar kwayar halittar agogo. Rushewar agogon jiki bi da bi yana da alaƙa da haɓakar cututtuka na yau da kullun.
Circadian rhythm ko kuma mu'agogon jiki' zagayen sa'o'i 24 ne wanda ke sarrafa canjin yanayin mu na yau da kullun da na tunani gami da barci. Wadannan jijiyoyi na jiki suna amsawa ga farko haske da duhu a cikin muhallinmu na kusa da lokacin cin abinci. A ilimin halittar jiki, an daidaita mutane don karɓar haske da abinci lokacin rana. An daidaita agogon jikin mu da kyau tare da yanayin waje. Wannan aiki tare yana da mahimmanci kuma shi ya sa duk lokacin da aka sami babban canji a agogon jikin mu, yana iya yin illa ga mu. kiwon lafiya. Misalin canje-canje kamar lokacin da wani ya yi aikin dare ko wani ya yi tafiya cikin yankunan lokaci.
Sanannen abu ne cewa rashin lokacin cin abinci, musamman cin abinci da daddare na iya kawo cikas ga agogon jikin mu wanda ke haifar da rashin lafiya, duk da haka, har yanzu ba a san takamaiman hanyar ba. Wani bincike da aka buga a cell a ranar 25 ga Afrilu, 2019 ya ba da shawarar cewa matakan sukari na jini suna daidaita hormone insulin da abubuwan haɓakar insulin (IGF-1) suna aiki azaman sigina na farko wanda ke sadar da lokacin cin abinci zuwa agogon jikin mu. Insulin yana fitowa kullum lokacin da muke cin abinci. A cikin wannan binciken, masu bincike sun sanya beraye ga insulin da IGF-1 a 'lokacin da ba daidai ba' watau lokacin da duhu kuma dabbobi suna barci. Sakamako ya nuna rushewa a cikin rhythm na circadian na mice saboda shigar da sunadaran sunadaran lokaci (PERIOD proteins) a lokacin da ba daidai ba lokacin da mice ba sa buƙatar yin aiki. PERIOD guda uku sunadaran sunadarin kamanni PER1, PER2 da PER3 sune manyan sassan agogon circadian na dabbobi masu shayarwa. Wannan haɓakar rashin lokaci a cikin sunadaran PER ya shafi ilimin halittar jiki na circadian na beraye, ɗabi'a da bayanin yanayin agogo. Bambance-bambancen da ake ganin beraye tsakanin dare da rana sun yi duhu.
insulin da IGF-1 sun kasance suna tasiri wajen rinjayar agogon jiki a cikin binciken da suka gabata amma ba a san tsarin su ba. An yi tunanin cewa aikin nasu na iya iyakance ga ƴan kyallen takarda a cikin jiki. Abubuwan da suka hana kafa aikin su shine faffadan rarraba su, rashin fa'ida mara kyau da raguwar sashi tsakanin insulin da IGF-1.
Wannan sabon binciken ya nuna cewa samar da insulin na yau da kullun yana hade da cin abinci mara lokaci yana rushe rugar jiki kuma yana shafar lafiyar mutum. Wannan rugujewar agogon jiki yana da alaƙa da haɓaka haɗari da tsananin cututtukan da suka haɗa da nau'in ciwon sukari na 2, kiba da cututtukan zuciya. Don haka, lokacin cin abinci da hasken haske yana da mahimmanci don kiyaye agogon jiki lafiya. Fahimtar yadda agogon jikin mu ke amsawa da kuma daidaitawa ga canje-canje a cikin haske da lokacin cin abinci yana da mahimmanci ga masu aikin dare, masu rashin barci musamman matasa da yawan tsufa.
***
{Zaku iya karanta ainihin takardar bincike ta danna hanyar haɗin DOI da aka bayar a ƙasa a cikin jerin tushen(s) da aka ambata}}
Source (s)
Crosby P. 2019. Insulin/IGF-1 Yana Korar PERIOD Haɗa zuwa Haɓaka Rhythms na Circadian tare da Lokacin Ciyarwa. Cell. https://doi.org/10.1016/j.cell.2019.02.017
