Barci da ke da nasaba da damuwa da matsalolin ƙwaƙwalwar ajiya sune mahimmancin matsalar lafiya da ke fuskantar mutane da yawa. Corticotropin-releasing hormone (CRH) neurons a cikin paraventricular tsakiya (PVN) a cikin hypothalamus suna taka muhimmiyar rawa a haɓaka matakan cortisol don amsa damuwa duk da haka Hanyar neuronal ba a sani ba. A cikin wani binciken da aka yi kwanan nan kan berayen dakin gwaje-gwaje, masu bincike sun gano cewa haɓakar ƙwayoyin ƙwayoyin cuta na corticotropin da ke sakin hormone neurons a cikin tsakiyar tsakiya na hypothalamus (CRH).PVN) Har ila yau, ya haifar da rushewar barci da rashin ƙwaƙwalwar ajiya, kama da sakamakon da aka haifar da damuwa ta ƙuntatawa, wato, duka damuwa da ƙarfafawa na CRH.PVN neurons sun haifar da illa iri ɗaya akan barci da ƙwaƙwalwa. Akasin haka, tasirin barci da ƙwaƙwalwar ajiya sun bambanta, watau barci da ƙwaƙwalwar ajiya sun inganta lokacin CRHPVN neurons sun toshe. Sakamakon binciken ya nuna cewa mummunan tasirin damuwa akan barci da ƙwaƙwalwar ajiya ana tsara su ta CRHPVN hanyoyin neuronal. Tun da hana CRHPVN neurons a lokacin damuwa yana inganta ayyukan barci da ƙwaƙwalwar ajiya, ƙaddamar da CRHPVN Hanyoyin neuronal na iya zama kyakkyawan dabara don maganin barci mai alaka da damuwa da matsalolin ƙwaƙwalwar ajiya.
danniya yanayi ne na damuwa da damuwa sakamakon mawuyacin yanayi na rayuwa. Amsa ce ta dabi'a wacce ta sa mu magance batutuwa da barazanar da ke gabanmu. Kowa yana fuskantar damuwa a wani lokaci a rayuwa. Yana shafar lafiyarmu da jin daɗinmu idan ba a kula da mu ba yadda ya kamata. Ɗayan mahimman tasirin damuwa shine rushewa a cikin barci da rashin ƙwaƙwalwar ajiya.
Jikinmu yana amsa damuwa ta hanyar samar da cortisol, "hormone damuwa." A cikin yanayi masu damuwa, hypothalamus yana ɓoye corticotropin-releasing hormone (CRH) wanda hakan zai haifar da glandon pituitary don haɗa corticotropin ko adrenocorticotropic hormone (ACTH), a matsayin wani ɓangare na hypothalamic-pituitary-adrenal. axis (HPA axis). Corticotropin yana ƙarfafa cortex na adrenal don haɗawa da sakin corticosteroids, galibi glucocorticoids. Girman matakin cortisol yana haifar da rushewar tsarin bacci da ɓarna a cikin rhythm na circadian don haka faruwar matsalolin barci masu alaƙa da damuwa. Hypothalamus yana taka muhimmiyar rawa a cikin wannan, musamman corticotropin-releasing hormone (CRH) neurons a cikin tsakiya na paraventricular (PVN) a cikin hypothalamus. Koyaya, hanyoyin yadda damuwa ke haifar da bacci da rikicewar ƙwaƙwalwar ajiya ba su da tabbas. Wani bincike na baya-bayan nan ya duba wannan.
Don bincika yadda corticotropin-releasing hormone (CRH) ɓoye neurons a cikin tsakiya na paraventricular (PVN) a cikin hypothalamus yana da alaƙa da bacci mai alaƙa da rikicewar ƙwaƙwalwar ajiya, masu binciken sun haifar da damuwa a cikin berayen dakin gwaje-gwaje ta hanyar hana su a cikin bututun filastik. An gano cewa berayen da suka damu sun dagula barci. Sun kuma kokawa da ƙwaƙwalwar sararin samaniya lokacin da aka gwada su a rana mai zuwa. Wadannan tasirin damuwa akan barci da ƙwaƙwalwar ajiya a cikin berayen dakin gwaje-gwaje sun kasance akan layin da ake tsammani. Masu binciken sun bincika idan haɓakawar corticotropin-sakin hormone ɓoye ƙwayoyin ƙwayoyin cuta a cikin tsakiya na paraventricular (CRH).PVN) na hypothalamus ya haifar da irin wannan tasiri akan barci da ƙwaƙwalwar ajiya a cikin mice marasa ƙarfi.
Abin sha'awa, kunna ƙwayoyin ƙwayoyin cuta masu sakin corticotropin a cikin tsakiyar tsakiya na hypothalamus (CRH).PVN) Har ila yau, ya haifar da rushewar barci da rashin ƙwaƙwalwar ajiya, kama da sakamakon da aka haifar da damuwa ta ƙuntatawa, wato, duka damuwa da ƙarfafawa na CRH.PVN neurons sun haifar da tasiri iri ɗaya akan barci da ƙwaƙwalwa. Akasin haka, tasirin barci da ƙwaƙwalwar ajiya sun bambanta, watau barci da ƙwaƙwalwar ajiya sun inganta lokacin CRHPVN neurons sun toshe.
Sakamakon da ke sama yana nuna cewa mummunan tasirin damuwa akan barci da ƙwaƙwalwar ajiya ana tsara su ta CRHPVN hanyoyin neuronal. Wannan yana da mahimmanci. Tun da hana CRHPVN neurons a lokacin damuwa yana inganta ayyukan barci da ƙwaƙwalwar ajiya, maganin barci mai alaka da damuwa da ƙwaƙwalwar ƙwaƙwalwa ta hanyar toshe CRH.PVN hanyoyin neuronal na iya zama mai yiwuwa a nan gaba. Ci gaban da ake samu a halin yanzu ƙaramin mataki ne na gaba a wannan hanyar.
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References:
- Wiest, A., et al 2025. Matsayin hypothalamic CRH neurons a cikin daidaita tasirin damuwa akan ƙwaƙwalwar ajiya da barci. Jaridar Neuroscience. An buga 9 Yuni 2025. DOI: https://doi.org/10.1523/JNEUROSCI.2146-24.2025
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 neurons in the paraventricular nucleus (PVN) in the hypothalamus play a pivotal role in elevation of cortisol levels in response to stress however neuronal pathway is unknown. In a recent study on laboratory mice, researchers found that stimulation of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus (CRHPVN) also produced disrupted sleep and impaired memory, similar to effects produced by the restraint stress, viz., both stress and stimulation of CRHPVN neurons produced same adverse effects on sleep and memory. Conversely, effects on sleep and memory were opposite, i.e., sleep and memory improved when CRHPVN neurons were blocked. The findings suggest that the adverse effects of stress on sleep and memory are regulated by CRHPVN neuronal pathways. Since inhibiting CRHPVN neurons during stress improves sleep and memory functions, targeting CRHPVN neuronal pathways may be a good strategy for treatment of stress-related sleep and memory disorders.){kind=link}