Daidaita tsarin farkawa da bacci da zagayowar rana yana da mahimmanci ga lafiya mai kyau. WHO ta rarraba rushewar agogon jiki a matsayin mai yiwuwa carcinogenic a yanayi. Wani sabon bincike a cikin BMJ ya binciki tasirin halayen barci kai tsaye (fifin safiya ko maraice, tsawon lokacin barci da rashin barci) kan haɗarin kamuwa da cutar kansar nono kuma ya gano cewa matan da ke son tashi da sassafe suna da ƙarancin haɗari, kuma idan Tsawon lokacin barci ya fi sa'o'i 7-8 yana ƙara haɗarin ciwon nono.
Hukumar Kula da Lafiya ta Duniya don Bincike akan Cancer yana rarraba aikin motsi wanda ya haɗa da rushewar circadian a matsayin mai yiwuwa carcinogenic ga mutane. Shaidu suna nuni zuwa ga kyakkyawar haɗi tsakanin rushewa a agogon jiki da haɓaka ciwon daji hadarin.
Bincike ya nuna cewa mata masu aikin dare sun fi yawa hadarin kansar nono saboda rushewar agogon jiki na ciki wanda ya haifar da rashin daidaituwa da yanayin bacci, fallasa haske a cikin sa'o'in faɗuwar rana da kuma canje-canjen salon rayuwa. Duk da haka, ba yawancin bincike sun mayar da hankali kan binciken ƙungiyoyi tsakanin mutum ba halayen barci (a) nau'in nau'in mutum watau lokacin barci da ayyukan yau da kullun (tsayin barcin barci) (b) tsawon lokacin barci da (c) rashin barci mai hadarin kansar nono. Bayar da rahoton kai ta mata a cikin binciken lura yana da saurin kuskure ko rikicewar da ba a auna ba don haka yin bayyani kai tsaye game da alaƙa tsakanin waɗannan halayen bacci da haɗarin cutar kansar nono yana da ƙalubale sosai.
Wani sabon binciken da aka buga a ranar 26 ga Yuni a BMJ da nufin bincika illolin da ke haifar da halayen barci kan haɗarin kamuwa da cutar sankarar nono ta hanyar amfani da hanyoyin haɗin gwiwa. Masu bincike sun yi amfani da manyan albarkatu masu inganci guda biyu - UK Biobank da binciken BCAC (Consortium Association of Cancer Association). Binciken Biobank na UK yana da mahalarta mata 180,216 daga zuriyar Turai waɗanda 7784 daga cikinsu sun sami cutar kansar nono. Mahalarta mata 228,951, suma 'yan asalin Turai, a binciken BCAC wanda 122977 suka kasance nono. ciwon daji lokuta da 105974 sarrafawa. Waɗannan albarkatu sun ba da matsayin ciwon nono, abubuwan ruɗani (marasa aunawa) da kuma canjin kwayoyin halitta.
Mahalarta sun kammala tambayoyin da suka haɗa da bayanan zamantakewa, salon rayuwa, tarihin iyali, tarihin likitanci, abubuwan ilimin lissafi. A gefe guda, mahalarta sun ba da rahoton da kansu (a) chronotype watau safiya ko maraice (b) matsakaicin tsawon lokacin barci da (c) alamun rashin barci. Masu bincike sunyi nazarin bambance-bambancen kwayoyin halitta da ke hade da waɗannan halayen barci guda uku (wanda aka gano kwanan nan a cikin manyan nazarin haɗin gwiwar kwayoyin halitta) ta hanyar amfani da hanyar da ake kira Mendelian Randomization (MR). MR wata hanyar bincike ce ta nazari da ake amfani da ita don bincika alaƙar haddasawa tsakanin abubuwan haɗari masu iya canzawa da sakamakon lafiya ta amfani da bambance-bambancen kwayoyin halitta azaman gwaje-gwaje na halitta. Wannan hanya ba ta da yuwuwar samun tasiri ta hanyar abubuwan ruɗani idan aka kwatanta da nazarin lura na gargajiya. Dalilai da yawa waɗanda aka ɗauke su a matsayin masu ruɗar haɗin kai tsakanin halayen barci da haɗarin nono ciwon daji sun kasance shekaru, tarihin iyali na ciwon nono, ilimi, BMI, halayen barasa, motsa jiki da sauransu.
Binciken Mendelian na UK Biobank bayanai ya nuna cewa 'fificin safiya' (mutumin da ya tashi da sassafe kuma ya kwanta da wuri da yamma) yana da alaƙa da ƙananan haɗarin cutar kansar nono (mace 1 a cikin 100) idan aka kwatanta da 'magariba'. fifiko'. Shaidu kaɗan sun nuna yiwuwar haɗarin haɗari tare da tsawon lokacin barci da rashin barci. Binciken Mendelian na bayanan BCAC shima ya goyi bayan fifikon safiya kuma ya ƙara nuna cewa tsawon lokacin bacci wato fiye da sa'o'i 7-8 yana ƙara haɗarin kamuwa da cutar kansar nono. Shaidar rashin barci ba ta cika ba. Tunda hanyar MR tana ba da ingantaccen sakamako don haka idan an sami ƙungiya, yana nuna alaƙar kai tsaye. An ga shaidun sun yi daidai da waɗannan ƙungiyoyin dalilai guda biyu.
Binciken na yanzu ya haɗu da hanyoyi masu yawa don samun damar yin kima game da sakamakon sakamakon halayen barci a kan hadarin ciwon nono da farko, ciki har da bayanai daga manyan albarkatu guda biyu - UK Biobank da BCAC da na biyu, amfani da bayanan da aka samo daga rahoton kai. da ma'aunin barci da aka tantance daidai gwargwado. Bugu da ari, nazarin MR ya yi amfani da mafi yawan adadin SNPs da aka gano a cikin nazarin ƙungiyoyin genome har zuwa yau. Sakamakon binciken da aka ruwaito yana da tasiri mai ƙarfi don shawo kan kyawawan halayen barci a cikin jama'a (musamman kanana) don inganta lafiyar mutum. Sakamakon binciken zai iya taimakawa wajen haɓaka sabbin dabarun keɓancewa don rage haɗarin cutar kansa da ke da alaƙa da rushewar tsarin circadian ɗin mu.
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{Zaku iya karanta ainihin takardar bincike ta danna hanyar haɗin DOI da aka bayar a ƙasa a cikin jerin tushen(s) da aka ambata}}
Source (s)
1. Richmond RC et al. 2019. Binciken alaƙa tsakanin halayen barci da haɗarin ciwon nono a cikin mata: nazarin bazuwar mendelian. BMJ. http://dx.doi.org/10.1136/bmj.l2327
2. UK Biobank. https://www.ukbiobank.ac.uk/
3. Gamayyar Kungiyar Ciwon Kansa. http://bcac.ccge.medschl.cam.ac.uk/
