Gwargwadon kwayar halittar Phf21b an san yana da alaƙa da ciwon daji da damuwa. Wani sabon bincike a yanzu ya nuna cewa bayyanar da wannan kwayar halitta a kan lokaci tana taka muhimmiyar rawa a bambance-bambancen kwayoyin halitta na jijiyoyi da haɓakar kwakwalwa.
Wani sabon bincike da aka buga a cikin mujallar Genes and Development akan 20 Maris 2020, yana nuna rawar da furotin na Phf21b wanda PHF21B ke ɓoyewa. gene a cikin bambance-bambancen cell stem jijiyoyi. Bugu da kari, shafe Phf21b a cikin vivo, ba wai kawai hana bambance-bambancen sel na jijiyoyi ba amma kuma ya haifar da sel progenitor na cortical don yin saurin hawan tantanin halitta. Binciken na yanzu na masu bincike a Jami'ar Sarauniya na Belfast yana nuna lokacin da ake magana da furotin phf21b a matsayin mahimmanci ga bambance-bambancen kwayar halitta na jijiyoyi yayin ci gaban cortical.1. Matsayin Phf21b a cikin bambance-bambancen ƙwayoyin ƙwayoyin jijiyoyi suna wakiltar wani muhimmin mataki a cikin fahimtar neurogenesis a cikin ci gaban kwayoyin halitta kuma zai inganta fahimtarmu game da tsarin hadaddun tsarin. kwakwalwa ci gaba da tsarinsa wanda ba a fahimta ba har zuwa yanzu game da sauyawa tsakanin yaduwa da bambance-bambance a lokacin neurogenesis.
Labarin Saukewa: PHF21B Za a iya danganta kwayar halittar ta fara kimanin shekaru ashirin da suka gabata lokacin da a cikin shekara ta 2002, Nazarin PCR na ainihi ya nuna cewa shafe 22q.13 yankin na chromosome 22 yana da mummunan tsinkaye a cikin ciwon daji na baki.2. An ƙara tabbatar da hakan bayan 'yan shekaru a cikin 2005 lokacin da Bergamo et al3 ya nuna ta amfani da nazarin cytogenetic cewa shafe wannan yanki na chromosome 22 yana da alaƙa da kai da wuyansa. cancers.
Kusan shekaru goma daga baya a cikin 2015, Bertonha da abokan aiki sun gano kwayar halittar PHF21B a sakamakon gogewar yankin 22q.134. An tabbatar da shafewar a cikin rukuni na kai da wuyan squamous cell carcinoma marasa lafiya da kuma rage yawan magana na PHF21B an danganta shi da hypermethylation yana tabbatar da matsayinsa a matsayin kwayar cutar ciwon daji. Shekara guda daga baya a cikin 2016, Wong et al ya nuna haɗin gwiwar wannan kwayar halitta a cikin baƙin ciki sakamakon babban damuwa wanda ke haifar da raguwar bayyanar PHF21B. 5.
Wannan binciken da ƙarin bincike kan nazarin maganganun phf21b a cikin sararin samaniya da lokaci zai ba da hanya don ganewar asali da wuri da kuma ingantaccen maganin cututtukan jijiya kamar baƙin ciki, rashin hankali da sauran su. kwakwalwa cututtuka masu alaƙa irin su Alzheimer's da Parkinson's.
***
References:
1. Basu A, Mestres I, Sahu SK, et al 2020. Phf21b yana buga maɓalli na spatiotemporal epigenetic canji mai mahimmanci don bambance-bambancen ƙwayar jijiyoyi. Genes & Dev. 2020. DOI: https://doi.org/10.1101/gad.333906.119
2. Reis, PP, Rogatto SR, Kowalski LP et al. PCR na ainihin-ƙididdige ƙididdigewa yana gano wani yanki mai mahimmanci na gogewa akan 22q13 mai alaƙa da tsinkaya a cikin kansar baka. Oncogene 21: 6480-6487, 2002. DOI: https://doi.org/10.1038/sj.onc.1205864
3. Bergamo NA, da Silva Veiga LC, dos Reis PP et al. Nazarce-nazarcen cytogenetic na al'ada da kwayoyin halitta sun bayyana nasarorin chromosomal da asarar da ke da alaƙa da rayuwa a cikin masu cutar kansa da wuya. Clin. Ciwon daji Res. 11: 621-631, 2005. Akwai akan layi a https://clincancerres.aacrjournals.org/content/11/2/621
4. Bertonha FB, Barros Filho MdeC, Kuasne H, dos Reis PP, da Costa Prando E., Munoz JJAM, Roffe M, Hajj GNM, Kowalski LP, Rainho CA, Rogatto SR. PHF21B a matsayin ɗan takara mai hana ƙwayar ƙwayar cuta a cikin kansa da wuyansa squamous cell carcinomas. Molec. Oncol. 9: 450-462, 2015. DOI: https://doi.org/10.1016/j.molonc.2014.09.009
5. Wong M, Arcos-Burgos M, Liu S et al. The Saukewa: PHF21B gene yana da alaƙa da babban baƙin ciki kuma yana daidaita amsa damuwa. Mol Ilimin Halitta 22, 1015-1025 (2017). DOI: https://doi.org/10.1038/mp.2016.174
***
