Barci da ke da nasaba da damuwa da matsalolin ƙwaƙwalwar ajiya sune mahimmancin matsalar lafiya da ke fuskantar mutane da yawa. Corticotropin-releasing hormone (CRH) neurons a cikin paraventricular tsakiya (PVN) a cikin hypothalamus suna taka muhimmiyar rawa a haɓaka matakan cortisol don amsa damuwa duk da haka Hanyar neuronal ba a sani ba. A cikin wani binciken da aka yi kwanan nan kan berayen dakin gwaje-gwaje, masu bincike sun gano cewa haɓakar ƙwayoyin ƙwayoyin cuta na corticotropin da ke sakin hormone neurons a cikin tsakiyar tsakiya na hypothalamus (CRH).PVN) Har ila yau, ya haifar da rushewar barci da rashin ƙwaƙwalwar ajiya, kama da sakamakon da aka haifar da damuwa ta ƙuntatawa, wato, duka damuwa da ƙarfafawa na CRH.PVN neurons sun haifar da illa iri ɗaya akan barci da ƙwaƙwalwa. Akasin haka, tasirin barci da ƙwaƙwalwar ajiya sun bambanta, watau barci da ƙwaƙwalwar ajiya sun inganta lokacin CRHPVN neurons sun toshe. Sakamakon binciken ya nuna cewa mummunan tasirin damuwa akan barci da ƙwaƙwalwar ajiya ana tsara su ta CRHPVN hanyoyin neuronal. Tun da hana CRHPVN neurons a lokacin damuwa yana inganta ayyukan barci da ƙwaƙwalwar ajiya, ƙaddamar da CRHPVN Hanyoyin neuronal na iya zama kyakkyawan dabara don maganin barci mai alaka da damuwa da matsalolin ƙwaƙwalwar ajiya.
Damuwa yanayi ne na damuwa da damuwa da yanayi mai wahala a rayuwa ke haifarwa. Amsa ce ta halitta da ke sa mu magance matsalolin da barazanar da ke gabanmu. Kowa yana fuskantar damuwa a wani lokaci a rayuwa. Yana shafar lafiyarmu da walwalarmu idan ba a sarrafa shi ba kuma ba a magance shi yadda ya kamata ba. Ɗaya daga cikin manyan tasirin damuwa shine katsewar barci da rashin iya tunawa.
Jikinmu yana mayar da martani ga damuwa ta hanyar samar da cortisol, "hormone na damuwa." A cikin yanayi mai damuwa, hypothalamus yana fitar da corticotropin-releasing hormone (CRH) wanda hakan ke motsa glandar pituitary don samar da corticotropin ko adrenocorticotropic hormone (ACTH), a matsayin wani ɓangare na hypothalamic-pituitary-adrenal axis (HPA axis). Corticotropin yana motsa adrenal cortex don haɗawa da sakin corticosteroids, galibi glucocorticoids. Matsayin cortisol mai yawa yana haifar da rashin daidaituwa a cikin yanayin barci da canje-canje a cikin yanayin circadian don haka faruwar matsalolin barci da suka shafi damuwa. Hypothalamus yana taka muhimmiyar rawa a cikin wannan, musamman ƙwayoyin halittar corticotropin-releasing hormone (CRH) a cikin paraventricular nucleus (PVN) a cikin hypothalamus. Duk da haka, hanyoyin da damuwa ke haifar da matsalolin barci da ƙwaƙwalwa ba a fayyace su ba. Wani bincike na baya-bayan nan ya duba wannan.
Domin bincika yadda sinadarin corticotropin-releasing hormone (CRH) da ke fitar da ƙwayoyin jijiyoyi a cikin ƙwayoyin paraventricular (PVN) a cikin hypothalamus ke da alaƙa da matsalolin barci da ƙwaƙwalwa da suka shafi damuwa, masu binciken sun haifar da damuwa a cikin beraye masu dakin gwaje-gwaje ta hanyar hana su a cikin bututun filastik. An gano cewa beraye masu damuwa suna da matsalar barci. Sun kuma yi fama da ƙwaƙwalwar sarari lokacin da aka gwada su washegari. Waɗannan tasirin damuwa akan barci da ƙwaƙwalwa a cikin beraye masu dakin gwaje-gwaje suna kan layin da ake tsammani. Daga nan masu binciken suka bincika ko ƙarfafawar hormone corticotropin-releasing hormone da ke fitar da ƙwayoyin jijiyoyi a cikin ƙwayoyin paraventricular (CRH PVN ) na hypothalamus ya haifar da irin wannan tasirin akan barci da ƙwaƙwalwa a cikin beraye marasa damuwa.
Abin sha'awa, kunna ƙwayoyin hormones masu sakin corticotropin a cikin ƙwayar paraventricular na hypothalamus (CRH PVN ) shi ma ya haifar da rashin barci da rashin ƙwaƙwalwar ajiya, kama da tasirin da damuwa ta hana aiki ke haifarwa, wato, damuwa da ƙarfafa ƙwayoyin CRH PVN sun haifar da irin wannan tasiri akan barci da ƙwaƙwalwa. Akasin haka, tasirin barci da ƙwaƙwalwa akasin haka ne, watau, barci da ƙwaƙwalwa sun inganta lokacin da aka toshe ƙwayoyin CRH PVN .
Sakamakon da ke sama ya nuna cewa illolin damuwa ga barci da ƙwaƙwalwa suna ƙarƙashin tsarin hanyoyin jijiyoyi na CRH PVN . Wannan yana da mahimmanci. Tunda hana ƙwayoyin jijiyoyi na CRH PVN yayin damuwa yana inganta ayyukan barci da ƙwaƙwalwa, maganin matsalolin barci da ƙwaƙwalwa da suka shafi damuwa ta hanyar toshe hanyoyin jijiyoyi na CRH PVN na iya yiwuwa a nan gaba. Ci gaban da ake samu a yanzu ƙaramin mataki ne na gaba a wannan alkibla.
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References:
- Wiest, A., et al 2025. Matsayin hypothalamic CRH neurons a cikin daidaita tasirin damuwa akan ƙwaƙwalwar ajiya da barci. Jaridar Neuroscience. An buga 9 Yuni 2025. DOI: https://doi.org/10.1523/JNEUROSCI.2146-24.2025
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 neurons in the paraventricular nucleus (PVN) in the hypothalamus play a pivotal role in elevation of cortisol levels in response to stress however neuronal pathway is unknown. In a recent study on laboratory mice, researchers found that stimulation of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus (CRHPVN) also produced disrupted sleep and impaired memory, similar to effects produced by the restraint stress, viz., both stress and stimulation of CRHPVN neurons produced same adverse effects on sleep and memory. Conversely, effects on sleep and memory were opposite, i.e., sleep and memory improved when CRHPVN neurons were blocked. The findings suggest that the adverse effects of stress on sleep and memory are regulated by CRHPVN neuronal pathways. Since inhibiting CRHPVN neurons during stress improves sleep and memory functions, targeting CRHPVN neuronal pathways may be a good strategy for treatment of stress-related sleep and memory disorders.){kind=link}