IGF-1: Kasuwancin Kashe Tsakanin Ayyukan Fahimta da Hadarin Ciwon daji

Factor 1 na girma kamar insulin (IGF-1) wani muhimmin abu ne na girma wanda ke gudanar da yawancin tasirin da ke haɓaka girma na hormone girma (GH) ta hanyar ƙarfafa GH na sakin IGF-1 daga hanta. ^1. Siginar IGF-1 tana haɓaka girma da yaɗuwar cutar kansa kuma an haɓaka magunguna don kai hari ga mai karɓar IGF-1 (IGF1R) don rage siginar IGF-1, kodayake ba shi da tasiri saboda juriya ga magungunan da ake samarwa a cikin marasa lafiya ^2. An sanya IGF-1 a matsayin abin haɗari ga ciwon daji na prostate kuma yawan matakan IGF-1 a cikin jini suna da alaƙa da nau'ikan ciwon daji daban-daban ^2. Duk da haka, saboda tasirinsa na haɓaka girma, gami da a cikin kwakwalwa, raguwar siginar IGF-1 a cikin kwakwalwa yana da alaƙa da ƙaruwar cutar Alzheimer (AD) da haɗarin dementia, raguwar fahimta, damuwa da baƙin ciki ² wanda ke nuna ciniki tsakanin aikin fahimta da haɗarin cutar kansa.

Beraye masu ƙarancin sinadarin IGF-1 a cikin jini suna da ƙarancin fahimi wanda ake juyawa lokacin da aka ba wa beraye IGF-1 ^. Dukansu masu karɓar insulin (IR) da IGF1R suna ƙarfafa rarrabuwar ƙwayoyin halitta, don haka suna haɓaka ciwon daji ^2. Koyo da ƙwaƙwalwa suna buƙatar siginar insulin/IGF-1 kuma ƙaruwar IGF-1 yana da alaƙa da ingantaccen ƙwaƙwalwa da ƙaruwar yawan hippocampus ^2. Bugu da ƙari, a cikin marasa lafiya da ke fama da cutar Parkinson (PD) waɗanda ke da ƙarancin matakan IGF-1 a cikin jini, suna da ƙarancin aiki a kan ayyukan da ke gwada aikin fahimi ^2. Duk da haka, abin sha'awa, IGF-1 na iya rage gudu wajen share plaque na beta-amyloid wanda ke ba da gudummawa ga AD ² , amma da alama daga shaidar cewa IGF-1 gabaɗaya yana da matuƙar pro-cognition, pro-neurogenesis da neuroprotective.

Misali bayyananne na wannan canjin shine raguwar haɗarin AD a tsakanin masu fama da cutar kansa , da kuma cewa tsofaffi masu fama da cutar kansa suna da ƙwaƙwalwar ajiya mai kyau tare da ƙarancin raguwar aikin ƙwaƙwalwa ^2. Don haka, da alama babu matsala a yi bayani cewa IGF-1 , kamar yawancin abubuwa, yana da fa'idodi da haɗari da ke tattare da shi, kuma babu wata hanya mai sauƙi ta zama "mai lafiya" ta hanyar sarrafa IGF-1 ta hanyar canje-canjen rayuwa kamar azumi da ƙuntatawa makamashi don rage yawan sinadarinsa a cikin jini, kamar yadda rage yawan sinadarin na iya haifar da sakamako mara kyau na fahimta wanda ke sa mutum ya zama "mara lafiya".

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References:  

1. Laron Z. (2001). Insulin-kamar girma factor 1 (IGF-1): wani girma hormone. Kwayoyin halitta Pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311 

2. Rosenzweig SA tarihin farashi a 2020 Ci gaba da Juyin Halitta na Siginar Factor Factor Insulin-kamar. F1000Bincike, 9, F1000 Faculty Rev-205. https://doi.org/10.12688/f1000research.22198.1 

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