Hanyar Novel don 'Maidawa' Magungunan da suka wanzu Don COVID-19

Haɗin hanyar nazarin halittu da lissafi don nazarin hulɗar furotin-protein (PPIs) tsakanin ƙwayoyin cuta da furotin mai masaukin baki don gano da kuma sake amfani da magunguna don ingantaccen magani na COVID-19 da wataƙila wasu cututtuka.

Dabaru na yau da kullun don magance cututtukan ƙwayoyin cuta sun haɗa da ƙirƙirar magungunan hana ƙwayoyin cuta da haɓaka alluran rigakafi. A cikin rikicin da ba a taɓa gani ba a yanzu, duniya tana fuskantar COVID-19 wanda ƙwayar cuta ta SARS-CoV-2 ta haifar , sakamakon daga hanyoyin biyu da ke sama sun yi kama da sun yi nisa sosai don samar da duk wani sakamako mai kyau.

Wata ƙungiyar masu bincike ta ƙasa da ƙasa kwanan nan (1) ta ɗauki wata sabuwar hanya (bisa ga yadda ƙwayoyin cuta ke hulɗa da masu masaukin baki) don "sake amfani" da magungunan da ake da su wajen gano sabbin magunguna da ake samarwa, waɗanda za su iya taimakawa wajen yaƙi da kamuwa da cutar COVID-19 yadda ya kamata. Domin fahimtar yadda SARS-CoV-2 ke hulɗa da mutane, masu binciken sun yi amfani da haɗakar dabarun halittu da lissafi don ƙirƙirar "taswirar" sunadaran ɗan adam waɗanda sunadaran ƙwayoyin cuta ke hulɗa da su kuma suke amfani da su don haifar da kamuwa da cuta a cikin mutane. Masu binciken sun sami damar gano sunadaran ɗan adam sama da 300 waɗanda ke hulɗa da sunadaran ƙwayoyin cuta guda 26 da aka yi amfani da su a cikin binciken (2). Mataki na gaba shine gano wanne daga cikin magungunan da ake da su da kuma waɗanda ake haɓakawa waɗanda za a iya " sake amfani da su " don magance kamuwa da cutar COVID-19 ta hanyar niyya ga waɗannan sunadaran ɗan adam.

Binciken ya haifar da gano nau'ikan magunguna guda biyu waɗanda za su iya magance su yadda ya kamata da rage cutar COVID-19: masu hana fassarar furotin ciki har da zotatifin da ternatin-4/plitidepsin, da magungunan da ke da alhakin daidaitawar furotin na Sigma1 da Sigma 2 masu karɓa a ciki cell ciki har da progesterone, PB28, PD-144418, hydroxychloroquine, magungunan antipsychotic haloperidol da cloperazine, siramesine, antidepressant da maganin damuwa, da antihistamines clemastine da cloperastine.

Daga cikin masu hana fassarar furotin, an ga tasirin antiviral mafi ƙarfi a cikin vitro akan COVID-19 tare da zotatifin, wanda a halin yanzu yana cikin gwajin asibiti don ciwon daji, da ternatin-4/plitidepsin, wanda FDA ta amince da shi don maganin myeloma da yawa.

Daga cikin magungunan da ke daidaita masu karɓar Sigma1 da Sigma2, antipsychotic haloperidol, da ake amfani da su don kula da schizophrenia, sun nuna aikin rigakafin cutar SARS-CoV-2. Magungunan antihistamines guda biyu masu ƙarfi, clemastine da cloperastine, suma sun nuna aikin rigakafin cutar, kamar yadda PB28 yayi. Tasirin rigakafin ƙwayoyin cuta da PB28 ya nuna ya kusan sau 20 fiye da hydroxychloroquine. Hydroxychloroquine, a gefe guda, ya nuna cewa, baya ga yin niyya ga masu karɓar Sigma1 da -2, kuma yana ɗaure da furotin da aka sani da hERG, wanda aka sani don daidaita ayyukan lantarki a cikin zuciya. Waɗannan sakamakon na iya taimakawa bayyana haɗarin haɗarin da ke tattare da amfani da hydroxychloroquine da abubuwan da suka samo asali a matsayin yuwuwar maganin COVID-19.

Kodayake binciken da aka ambata a sama a cikin vitro ya haifar da sakamako masu ban sha'awa, 'tabbacin pudding' zai dogara ne akan yadda waɗannan yuwuwar ƙwayoyin magunguna ke tafiya cikin gwaji na asibiti kuma suna haifar da ingantaccen magani ga COVID-19 nan ba da jimawa ba. Bambance-bambancen binciken shine ya fadada iliminmu kan fahimtarmu ta asali na yadda kwayar cutar ke hulɗa da mai watsa shiri wanda ke haifar da gano sunadaran sunadaran ɗan adam da ke hulɗa da sunadaran ƙwayoyin cuta da kuma bayyanar da mahadi waɗanda wataƙila ba a bayyana ba don yin nazari a cikin yanayin hoto.

Wannan bayanin da aka bayyana daga wannan binciken ba wai kawai ya taimaka wa masana kimiyya ba don gano masu neman magunguna da sauri don bin gwaje-gwaje na asibiti, amma ana iya amfani da su don fahimta da kuma hango tasirin magungunan da ke faruwa a asibitin kuma za'a iya ƙarawa don gano magunguna a kan wasu. cututtuka na hoto ko bidiyo mai zagaya yanar gizo da sauri.

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References:

1. Cibiyar Pasteur, 2020. Bayyana yadda SARS-COV-2 ke satar ƙwayoyin halittar ɗan adam; Yana nuna magunguna masu yuwuwar yaƙi da COVID-19 da kuma wani magani da ke taimakawa wajen yaɗuwar cutar. SANARWA TA SANARWA An buga a ranar 30 ga Afrilu 2020. Akwai a yanar gizo a https://www.pasteur.fr/en/research-journal/press-documents/revealing-how-sars-cov-2-hijacks-human-cells-points-drugs-potential-fight-covid-19-and-drug-aids-its An shiga ranar 06 ga Mayu 2020.

2. Gordon, DE da sauransu. 2020. Taswirar hulɗar furotin ta SARS-CoV-2 ta bayyana abubuwan da za a yi amfani da su wajen sake amfani da magunguna. Yanayi (2020). DOI: https://doi.org/10.1038/s41586-020-2286-9

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