Hanyar Novel don 'Maidawa' Magungunan da suka wanzu Don COVID-19

Haɗin tsarin ilimin halitta da na lissafi don nazarin hulɗar furotin-gina jiki (PPI) tsakanin ƙwayoyin cuta da ƙwayoyin cuta don ganowa da sake dawo da magunguna don ingantaccen magani na COVID-19 da yuwuwar sauran cututtuka suma..

Dabarun da aka saba don magance cututtukan ƙwayoyin cuta sun haɗa da tsara magungunan rigakafin cutar da haɓaka rigakafin. A cikin rikicin da ba a taba ganin irinsa ba, duniya na fuskantar sa saboda Covid-19 sakamakon SARS-CoV-2 virus, Sakamako daga duka hanyoyin da ke sama da alama suna da nisa don sadar da kowane sakamako mai bege.

Tawagar masu bincike na kasa da kasa kwanan nan (1) sun dauki sabon salo (bisa yadda ƙwayoyin cuta ke hulɗa da rundunonin) don “sake manufar” magungunan da ke akwai waɗanda ke gano sabbin magungunan da ke ƙarƙashin haɓakawa, waɗanda za su iya taimakawa yaƙi da kamuwa da COVID-19 yadda ya kamata. Don fahimtar yadda SARS-CoV-2 ke hulɗa da mutane, masu binciken sun yi amfani da haɗin gwiwar ilimin halitta da dabarun lissafi don ƙirƙirar “taswirar” sunadaran ɗan adam waɗanda sunadaran ƙwayoyin cuta ke hulɗa da su kuma suke amfani da su don haifar da kamuwa da cuta a cikin mutane. Masu binciken sun sami damar gano sunadaran mutane sama da 300 waɗanda ke hulɗa da sunadaran ƙwayoyin cuta guda 26 da aka yi amfani da su a cikin binciken (2). Mataki na gaba shine gano wanene daga cikin magungunan da ake da su da kuma waɗanda ke kan haɓakawa wanda zai iya zama “sake"don magance cutar COVID-19 ta hanyar kai hari ga waɗannan sunadaran ɗan adam.

Binciken ya haifar da gano nau'ikan magunguna guda biyu waɗanda za su iya magance su yadda ya kamata da rage cutar COVID-19: masu hana fassarar furotin ciki har da zotatifin da ternatin-4/plitidepsin, da magungunan da ke da alhakin daidaitawar furotin na Sigma1 da Sigma 2 masu karɓa a ciki cell ciki har da progesterone, PB28, PD-144418, hydroxychloroquine, magungunan antipsychotic haloperidol da cloperazine, siramesine, antidepressant da maganin damuwa, da antihistamines clemastine da cloperastine.

Daga cikin masu hana fassarar furotin, an ga tasirin antiviral mafi ƙarfi a cikin vitro akan COVID-19 tare da zotatifin, wanda a halin yanzu yana cikin gwajin asibiti don ciwon daji, da ternatin-4/plitidepsin, wanda FDA ta amince da shi don maganin myeloma da yawa.

Daga cikin magungunan da ke daidaita masu karɓar Sigma1 da Sigma2, antipsychotic haloperidol, da ake amfani da su don kula da schizophrenia, sun nuna aikin rigakafin cutar SARS-CoV-2. Magungunan antihistamines guda biyu masu ƙarfi, clemastine da cloperastine, suma sun nuna aikin rigakafin cutar, kamar yadda PB28 yayi. Tasirin rigakafin ƙwayoyin cuta da PB28 ya nuna ya kusan sau 20 fiye da hydroxychloroquine. Hydroxychloroquine, a gefe guda, ya nuna cewa, baya ga yin niyya ga masu karɓar Sigma1 da -2, kuma yana ɗaure da furotin da aka sani da hERG, wanda aka sani don daidaita ayyukan lantarki a cikin zuciya. Waɗannan sakamakon na iya taimakawa bayyana haɗarin haɗarin da ke tattare da amfani da hydroxychloroquine da abubuwan da suka samo asali a matsayin yuwuwar maganin COVID-19.

Kodayake binciken da aka ambata a sama a cikin vitro ya haifar da sakamako masu ban sha'awa, 'tabbacin pudding' zai dogara ne akan yadda waɗannan yuwuwar ƙwayoyin magunguna ke tafiya cikin gwaji na asibiti kuma suna haifar da ingantaccen magani ga COVID-19 nan ba da jimawa ba. Bambance-bambancen binciken shine ya fadada iliminmu kan fahimtarmu ta asali na yadda kwayar cutar ke hulɗa da mai watsa shiri wanda ke haifar da gano sunadaran sunadaran ɗan adam da ke hulɗa da sunadaran ƙwayoyin cuta da kuma bayyanar da mahadi waɗanda wataƙila ba a bayyana ba don yin nazari a cikin yanayin hoto.

Wannan bayanin da aka bayyana daga wannan binciken ba wai kawai ya taimaka wa masana kimiyya ba don gano masu neman magunguna da sauri don bin gwaje-gwaje na asibiti, amma ana iya amfani da su don fahimta da kuma hango tasirin magungunan da ke faruwa a asibitin kuma za'a iya ƙarawa don gano magunguna a kan wasu. cututtuka na hoto ko bidiyo mai zagaya yanar gizo da sauri.

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References:

1. The Institut Pasteur, 2020. Bayyana yadda SARS-COV-2 ke sace ƙwayoyin ’yan Adam; Nuna magunguna waɗanda ke da yuwuwar yaƙar COVID-19 da kuma maganin da ke taimakawa haɓakar kamuwa da cuta. An buga SANARWA a ranar 30 ga Afrilu 2020. Akwai kan layi a https://www.pasteur.fr/en/research-journal/press-documents/revealing-how-sars-cov-2-hijacks-human-cells-points-drugs-potential-fight-covid-19-and-drug-aids-its An shiga ranar 06 ga Mayu 2020.

2. Gordon, DE et al. 2020. Taswirar hulɗar furotin na SARS-CoV-2 yana bayyana maƙasudin sake fasalin ƙwayoyi. Yanayi (2020). DOI: https://doi.org/10.1038/s41586-020-2286-9

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